ASMS 2012 Posters
Metabolic “Fingerprint” of Amodiaquine using on-line EC/MS.
Find out why you need to couple the most powerful Electrochemistry (EC) system with your LC/MS!
Posters presented at the 60th ASMS 2012 Conference in Vancouver
Recently, Electrochemistry (EC) is increasingly used to study redox reactions that take place in life sciences. Antec’s ROXY™ EC system allows to mimic many of these redox reactions within seconds that otherwise take place over several hours, weeks, months or even years in nature! The generated oxidation or reduction products are in well defined solutions, making cumbersome and costly isolation steps obsolete.
Typical applications of EC up-front MS are: prediction of drug/xenobiotic metabolism, synthesis of metabolites, mimicking oxidative damage of DNA, cleavage of disulfide bonds in proteins/peptides, protein/peptide oxidation (stress), protein/peptide desalting prior to MS, etc.
- Poster1 - Novel method for efficient reduction of disulfide bonds in peptides and proteins prior MS detection
Agnieszka Kraj; Hendrik-Jan Brouwer; Nico Reinhoud; Jean-Pierre Chervet;
Antec, Zoeterwoude, The Netherlands.
- Poster2 - High Resolution Multistage Mass Spectral Trees for Identification of Electrochemically Synthesized Metabolites
Agnieszka Kraj1, Miguel Rojas-Chertó2, Marco Ries3, Hendrik-Jan Brouwer1, Nico Reinhoud1, Thomas Hankemeier2,3, Rob J. Vreeken2, 3, Theo Reijmers2, 3, Jean-Pierre Chervet1
1Antec, Zoeterwoude, The Netherlands; 2Netherlands Metabolomics Centre, The Netherlands,3Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands
- Poster 3 - Insights into Nucleic Acids Oxidation by Electrochemistry/Liquid Chromatography/Mass Spectrometry
Robert Erb1, Sabine Plattner1, Martin Eysberg2, Jean-Pierre Chervet2, Herbert Oberacher1
1Institute of Legal Medicine, Innsbruck Medical University, Muellerstrasse 44, 6020 Innsbruck, Austria; 2Antec, Industrieweg 12, 2382 NV Zouterwoude, The Netherlands
In case of any questions feel free to contact us at support@myAntec.com.