Analysis of Azithromycin, Clarithromycin, Erythromycin, Roxithromycin and Azaerythromycin.
An ALEXYS system has been developed as a system solution for the analysis of Azithromycin following the official USP method. The USP method for Azi uses two flow cells in series, cell 1 for screening and cell 2 for detection of the analytes. The first flow cell is a Reactor cell, the second is the VT-03 cell. Under the specified LC conditions all USP criteria are met.
A mixture of several macrolides was analysed to illustrate the chromatographic performance of the method. All components are separated with at least a resolution of 2.5.
For the analysis of Azythromycin we selected the VT03 electrochemical cell. This cell not only has an excellent reproducibility but also the best possible detection sensitivity. A Reactor was used as pre-oxidation screening cell to meet USP requirements. The ALG is a USP L49 type of column.
The ALEXYS system comprises the following parts:
|180.0086C||ALEXYS Azithromycin Analyzer, USP|