ROXY Systems

Mimicking nature's redox reactions

• Fast synthesis of metabolites (µ-preparative)
• Rapid risk assessments of drug-protein binding
• Signal enhancement in MS
• Electrochemical cleavage of proteins/peptides
• Oxidative stress/damage of proteins, DNA, lipids, etc.

The on-line coupling of Electrochemistry (EC) with LC/MS has shown great potential for the investigation of drug metabolism. It offers fast electrochemical synthesis of drug metabolites for reliable quantification by mass spectrometry (MS) to be operated as a high throughput screening system. The ROXY EC system and the ROXY EC/LC system provide all the tools for EC/MS research.

For further explanation see the video recording of the ASMS presentation of prof Uwe Karst, and the computer animation on YouTube made by University of Twente. This computer animation is on YouTube and is made by University of Twente to demonstrate the traditional and electrochemistry/MS method for drug metabolite screening.

_{See also: A microfluidic chip for electrochemical conversions in drug metabolism studies, M. Odijk, A. Baumann, W. Lohmann, F. T. G. van den Brink, W. Olthuis, U. Karst and A. van den Berg, Lab Chip, 2009, 9, 1687-1693.}

For more information download a brochure, or contact us for a quote or any other questions.