ROXY EC for MS

Dedicated Electrochemistry system for EC/MS

• Single compound conversion (oxidation/reduction)
• Direct on-line EC/MS, without chromatography (LC)
• All parts supplied for immediate installation and use
• Fast metabolite profiling Phase 1 and 2 metabolism
• Huge time and cost savings

The ROXY™ EC is the ideal introduction system for Electrospray Ionization (ESI)-MS for single compound conversion. For known compounds (e.g., drug candidates, pollutants, pesticides, etc) a quick profiling and/or reconfirmation of potential metabolites is often sufficient for decision making. Therefore, target compounds can be directly infused through the electrochemical ReactorCell™ into the MS, often without the need of any liquid chromatographic separation (HPLC), making EC/MS a very powerful tool for fast metabolic profiling and related applications.

The resulting time and cost savings are substantial when compared with daunting in vivo or in vitro experiments. The ROXY™ EC System is supplied with a dual syringe infusion pump and all connecting tubing and parts for immediate installation and use.

System configuration

The ROXY EC System comprises the following parts:

• ROXY Potentiostat DCC
• Reactorcell incl MD, GC. Pt and Au electrode
• Syringe pump
• Dialogue software
• Tubing assembly

 For more details see under system components.

Notes

• 2300000 - Overview ROXY Publications
• 2300351 - Baumann et al. Metabolic studies of tetrazepam..
• 2300352 - Trumpler et al. Interaction of thimerosal with proteins..
• 2300353 - Baumann et al. Online EC ESI MS of nucleotides..
• 2300354 - Lohmann et al. EC and MS for metabolite generation..
• 2300358 - Baumann et al. review Online ECMS in drug metabolism studies..
• 2300385 - H. Chen et al. Online MS Analysis of Proteins Peptides following cleavage..
• Y2010 - Hoffmann et al, EC MS for mechanistic studies and simulation of oxidation processes in the environment
• Y2011 - Zhang et al, Coupling of LC with MS by DESI
• Y2011 - Zhang et al, Online Coupling of LC with MS by DESI
• Y2012 - Erb et al, An optimized EC LC MS method for studying guanosine oxidation
• 210_001A_04 - ROXY Event programming and Settings
• 210_001_07 - Oxidative Metabolism of Acetaminophen
• 210_002A_01 - ROXY ECLC system userdefined programs for AS 110
• 210_002_01 - Automated screening with ROXY ECLC system
• 210_003_01 - uPrepCell for Metabolite Synthesis
• 210_004_04 - Oxidative Metabolism of Amodiaquine

Posters

• 221_070_01 - Online EC MS A Powerful Tool for Fast Prediction of Phase I and II Drug Metabolism
• 221_076_01 - Expanding Role of Electrochemistry Mass Spectrometry in Life Sciences
• 221_077_01 - Novel method for efficient reduction of disulfide bonds in peptides and proteins prior MS detection
• 221_078_01 - Identification of electrochemically synthesized metabolites
• 221_079_01 - Insights into Nucleic Acids Oxidation by ElectrochemistryLiquid ChromatographyMass Spectrometry
• 221_090_01 - Degradation of Xenobiotics and Binding to Organic Matter by OnLine EC MS