ROXY EC/LC for MS

Dedicated Electrochemistry / LC system for EC/LC/MS

• Fast metabolic screening of numerous samples
• On-line EC/LC/MS of complex samples
• Compatibility with any MS via contact closure
• Mimicking oxidative stress/damage of proteins, DNA, lipids, etc.
• Simulating nature’s Redox reaction

With the introduction of the ROXY™ EC/LC System, Antec brings Electrochemistry (EC) to the fingertips of every mass spectrometrist, making on-line EC/LC/MS for automated screening of numerous samples available for the first time. The system is based on state-of-the-art fluidics, implementing the ReactorCell™ as part of the autosampler. Furthermore specifically designed liquid handling programs allow for the addition of reagents, making Phase II reactions, i.e., adduct formation, in drug/xenobiotic metabolism easily accessible. Other applications include the studies of covalent drug-protein binding or the studies of reagents, e.g., antioxidants on biopolymers and their biotransformation [1].
The system further comprises a binary high pressure gradient system to assure minimal dwell volume and access to a wide flow rate range, covering conventional HPLC (4.6 mm i.d. columns) down to microbore HPLC (1 mm i.d. columns).

[1] patent pending

ROXY EC/LC System

For detailed specifications on the ROXY EC/LC system, click on the links below:

• ROXY Potentiostats DCC
• AS 110 autosampler cool, micro, 10-PV
• OR 110 organiser
• LC 110 pump
• Reactorcell incl MD and GC electrodes
• Clarity software

Notes

• 2300351 - Baumann et al. Metabolic studies of tetrazepam..
• 2300352 - Trumpler et al. Interaction of thimerosal with proteins..
• 2300353 - Baumann et al. Online EC ESI MS of nucleotides..
• 2300354 - Lohmann et al. EC and MS for metabolite generation..
• 2300358 - Baumann et al. review Online ECMS in drug metabolism studies..
• 2300385 - H. Chen et al. Online MS Analysis of Proteins Peptides following cleavage..
• 210_001A_04 - ROXY Event programming and Settings
• 210_001_07 - Oxidative Metabolism of Acetaminophen
• 210_002A_01 - ROXY ECLC system userdefined programs for AS 110
• 210_002_01 - Automated screening with ROXY ECLC system
• 210_003_01 - uPrepCell for Metabolite Synthesis
• 210_004_04 - Oxidative Metabolism of Amodiaquine

Posters

• 221_023_01 - ECLCMS a Powerful Tool for Predicting Metabolic Processes
• 221_024_01 - Combining EC with LCMS a Powerful Analytical Technique
• 221_026_02 - Simulating Oxidative Metabolism using online ECMS
• 221_028_01 - Simulating nucleic acid oxidation using ECLCMS
• 221_029_02 - The New Panacea in Metabolomics, Proteomics and Genomics
• 221_030_01 - Simulating Oxidative Metabolism Using Online ECMS
• 221_050_001 - Protein Cleavage Disulfide Bonds Reduction Covalent DNA
• 221_051_001 - Online ElectrochemistryMS A Powerful Tool